A control theoretic three timescale model for analyzing energy management in mammalian cancer cells.

ABSTRACT: Interaction among different pathways, such as metabolic, signaling and gene regulatory networks, of cellular system is responsible to maintain homeostasis in a mammalian cell. Malfunctioning of this cooperation may lead to many complex diseases, such as cancer and type 2 diabetes. Timescale differences among these pathways make their integration a daunting task. Metabolic, signaling and gene regulatory networks have three different timescales, such as, ultrafast, fast and slow respectively. The article deals with this problem by developing a support vector regression (SVR) based three timescale model with the application of genetic algorithm based nonlinear controller. The proposed model can successfully capture the nonlinear transient dynamics and regulations of such integrated biochemica

SUBMITTER: Dasgupta A 

PROVIDER: S-EPMC7809419 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature