Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.

ABSTRACT:

Background and aim

We previously identified forkhead box (FOX) O4 mRNA as a predictor in gastric cancer (GC). However, the underlying mechanism has yet to be elucidated. We aimed to illustrate the mechanism by which FOXO4 regulated glycolysis under hypoxia in GC.

Methods

FOXO4 protein expression was investigated by immunohistochemical staining of 252 GC and their normal adjacent tissues. We restored or silenced FOXO4 expression in GC cell lines to explore the underlying mechanisms.

Results

FOXO4 was downregulated in GC. Loss of FOXO4 expression was validated in univariate and multivariate survival analysis as an independent prognostic predictor for overall survival (P < 0.05) and disease-free survival (P<0.05). Restored FOXO4 expression significantly impaired the glyc

SUBMITTER: Wang XH 

PROVIDER: S-EPMC7809603 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature