Membrane protein biogenesis by the EMC.

ABSTRACT: The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo-EM structures, and a third model based on partial high- and low-resolution structures, suggest how this is accomplished.

SUBMITTER: Alvira S 

PROVIDER: S-EPMC7809699 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature