Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development.

ABSTRACT: Schizophrenia (SZ) is a devastating brain disease that affects about 1% of world population. Among the top genetic associations, zinc finger protein 804A (ZNF804A) gene encodes a zinc finger protein, associated with SZ and biolar disorder (BD). Copy number variants (CNVs) of ZNF804A have been observed in patients with autism spectrum disorders (ASDs), anxiety disorder, and BD, suggesting that ZNF804A is a dosage sensitive gene for brain development. However, its molecular functions have not been fully determined. Our previous interactomic study revealed that ZNF804A interacts with multiple proteins to control protein translation and neural development. ZNF804A is localized in the cytoplasm and neurites in the human cortex and is expressed in various types of neurons, including pyramidal, d

SUBMITTER: Dong F 

PROVIDER: S-EPMC7809827 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature