TMPRSS2-ERG fusion impacts anterior tumor location in men with prostate cancer.

ABSTRACT:

Background

In prostate cancer (PCa), lack of androgen receptor (AR) regulated TMPRSS2-ETS-related gene (ERG) gene fusion (ERG^negative ) status has been associated with African American race; however, the implications of ERG status for the location of dominant tumors within the prostate remains understudied.

Methods

An African American-enriched multiinstitutional cohort of 726 PCa patients consisting of both African American men (AAM; n = 254) and European American men (EAM; n = 472) was used in the analyses. Methods of categorical analysis were used. Messenger RNA (mRNA) expression differences between anterior and posterior tumor lesions were analyzed using Wilcoxon rank-sum tests with multiple comparison corrections.

Results

Anti-ERG immunohistochemistry s

SUBMITTER: Yamoah K 

PROVIDER: S-EPMC7810127 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature