Toward early detection of Helicobacter pylori-associated gastric cancer.

ABSTRACT:

Background

Gastric cancer is typically diagnosed at a late stage, leading to poor prognoses. Helicobacter pylori is responsible for 70% of gastric cancers globally, and patients with this bacterial infection often present with early stages of the carcinogenic pathway such as inflammation or gastritis. Although many patients continue to progress to advanced-stage disease after antibacterial treatment, there are no follow-up screening protocols for patients with a history of H. pylori.

Methods

Several biomarkers (Lgr5, CD133, CD44) become upregulated during gastric carcinogenesis. A logistic regression model is developed using clinical data from 59 patients at different stages of the carcinogenic pathway to identify the likelihood of being at an advanced stage of disease for a

SUBMITTER: Walker R 

PROVIDER: S-EPMC7810132 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature