Conformational properties of l-fucose and the tetrasaccharide building block of the sulfated l-fucan from Lytechinus variegatus.

ABSTRACT: Although the 3D structure of carbohydrates is known to contribute to their biological roles, conformational studies of sugars are challenging because their chains are flexible in solution and consequently the number of 3D structural restraints is limited. Here, we investigate the conformational properties of the tetrasaccharide building block of the Lytechinus variegatus sulfated fucan composed of the following structure [l-Fucp4(SO₃^-)-α(1-3)-l-Fucp2,4(SO₃^-)-α(1-3)-l-Fucp2(SO₃^-)-α(1-3)-l-Fucp2(SO₃^-)] and the composing monosaccharide unit Fucp, primarily by nuclear magnetic resonance (NMR) experiments performed at very low temperatures and using H₂O as the solvent for the sugars rather than us

SUBMITTER: Bezerra FF 

PROVIDER: S-EPMC7810140 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature