An update on the role of common genetic variation underlying substance use disorders.

ABSTRACT:

Purpose of the review

Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss some next steps in addiction genetics.

Recent findings

Genome-wide association studies have substantiated the role of previously known variants (e.g., rs1229984 in ADH1B for alcohol) and identified several novel loci for alcohol, tobacco, cannabis, opioid and cocaine use disorders. SUDs are genetically correlated with psychiatric outcomes, while liability to substance use is inconsistently associated with these outcomes and more closely associated with lifestyle factors. Specific variant associations appear to differ somewhat across populations, although similar genes and syste

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC7810203 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature