Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors.

ABSTRACT:

Background

In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases. The available bothropic antivenoms are efficient in avoiding fatalities, but do not completely neutralize venom serine proteases, which are co-responsible for some disorders observed during envenomation.

Methods

In order to search for tools to improve the antivenom's, 6-mer peptides were designed based on a specific substrate for Bothrops jararaca venom serine proteases, and then synthesized, with the intention to selectively inhibit these enzymes.

Results

Using batroxobin as a snake venom serine protease model, two structurally similar inhibitor peptides were identifi

SUBMITTER: da Silva GM 

PROVIDER: S-EPMC7810238 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature