DNA Methylation Patterns in CD4+ T Cells of Naive and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand.

ABSTRACT:

Background

Early life environmental exposures can have lasting effects on the function of the immune system and contribute to disease later in life. Epidemiological studies have linked early life exposure to xenobiotics that bind the aryl hydrocarbon receptor (AhR) with dysregulated immune responses later in life. Among the immune cells influenced by developmental activation of the AhR are CD4+ T cells. Yet, the underlying affected cellular pathways via which activating the AhR early in life causes the responses of CD4+ T cells to remain affected into adulthood remain unclear.

Objective

Our goal was to identify cellular mechanisms that drive impaired CD4+ T-cell responses later in life following maternal exposure to an exogenous AhR ligand.

Methods

C57BL/6 mice were v

SUBMITTER: Burke CG 

PROVIDER: S-EPMC7810290 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature