Unexpected interactions between dolutegravir and folate: randomized trial evidence from South Africa.

ABSTRACT:

Objective

Dolutegravir exposure at conception was associated with a preliminary signal of increased infant neural tube defect risk. As low maternal folate levels are linked with neural tube defects, we aimed to assess serum folate concentrations in women starting dolutegravir.

Design

We analysed serum folate concentrations from stored plasma among women enrolled in the South African ADVANCE trial.

Methods

We compared changes in mean serum folate and occurrence of low serum folate (<14.0 nmol/l) at weeks 0, 12 and 24 across study arms. In ADVANCE, 1053 treatment-naïve participants were randomized to initiate tenofovir-alafenamide/emtricitabine + dolutegravir (TAF/FTC + DTG), tenofovir-disoproxil-fumarate (TDF)/FTC + DTG or TDF/FTC/efavirenz (EFV).

Results

Analys

SUBMITTER: Chandiwana NC 

PROVIDER: S-EPMC7810415 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature