Contemporary use of real-world data for clinical trial conduct in the United States: a scoping review.

ABSTRACT:

Objective

Real-world data (RWD), defined as routinely collected healthcare data, can be a potential catalyst for addressing challenges faced in clinical trials. We performed a scoping review of database-specific RWD applications within clinical trial contexts, synthesizing prominent uses and themes.

Materials and methods

Querying 3 biomedical literature databases, research articles using electronic health records, administrative claims databases, or clinical registries either within a clinical trial or in tandem with methodology related to clinical trials were included. Articles were required to use at least 1 US RWD source. All abstract screening, full-text screening, and data extraction was performed by 1 reviewer. Two reviewers independently verified all decisions.

Res

SUBMITTER: Rogers JR 

PROVIDER: S-EPMC7810452 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature