Clinical features and outcome of patients with primary central nervous system lymphoma admitted to the intensive care unit: a French national expert center experience.

ABSTRACT:

Introduction

To describe the reasons for intensive care unit (ICU) admission and to evaluate the outcomes and prognostic factors of patients with primary central nervous system lymphoma (PCNSL) admitted to the ICU.

Patients and methods

Retrospective observational cohort study of 101 PCNSL patients admitted to 3 ICUs over a two-decade period.

Results

Acute respiratory failure, mainly secondary to aspiration pneumonia and Pneumocystis jirovecii pneumonia, was the leading reason for ICU admission (33%). Aspiration pneumonia was more common in patients with brainstem tumor (67% vs. 0%, p < 0.001), whereas patients with intracranial hypertension were more frequently admitted for coma without seizures (61% vs. 9%, p = 0.004). Hospital and 6-month mortality were 47% and 53%,

SUBMITTER: Decavele M 

PROVIDER: S-EPMC7810601 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature