Stratification of Stage III colon cancer may identify a patient group not requiring adjuvant chemotherapy.

ABSTRACT:

Purpose

Adjuvant chemotherapy for colon cancer with lymph node involvement (Stage III) has been the standard of care since the 1990s. Meanwhile, considerable evolvement of surgery combined with dedicated histopathological examinations may have led to stage migration. Furthermore, prognostic factors other than lymph node involvement have proven to affect overall survival. Thus, adjuvant chemotherapy in Stage III colon cancer should be reconsidered. The objective was to compare recurrence rates and survival in stage III colon cancer patients treated with or without adjuvant chemotherapy. Further, to assess the impact of extensive mesenterectomy, lymph node stage and vascular invasion on outcome.

Methods

Consecutive patients operated for Stage III colon carcinoma between 31 Dec

SUBMITTER: Malik YG 

PROVIDER: S-EPMC7810647 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature