Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis.

ABSTRACT:

Purpose

Liver metastasis is observed in up to 50% of colorectal cancer (CRC) patients. Available treatment options are limited and disease recurrence is often. Chemokine receptor 5 (CCR5) has attracted attention as novel therapeutic target for treating cancers. In this study, we reinforced the importance of CCR5 as therapeutic target in CRC and its liver metastasis by applying in vitro, in vivo and clinical investigations.

Methods

By targeting CCR5 via siRNAs or an FDA approved antagonist (maraviroc), we investigated the ensuing antineoplastic effects in three CRC cell lines. An animal model for CRC liver metastasis was used to evaluate time-dependent expressional modulation of the CCR5 axis by cDNA microarray. The model was also used to evaluate the in vivo efficacy of targ

SUBMITTER: Pervaiz A 

PROVIDER: S-EPMC7810651 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature