Elucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progeny.

ABSTRACT: Helminths are large multicellular parasites that infect one quarter of the human population. To prolong their survival, helminths suppress the immune responses of their hosts. Strongyloides ratti delays its expulsion from the gut by induction of regulatory circuits in a mouse strain-specific manner: depletion of Foxp3⁺ regulatory T cells (Treg) improves the anti-S. ratti immunity in BALB/c but not in C57BL/6 mice. In the current study we compare the hierarchy of immunoregulatory pathways in BALB/c, C57BL/6 mice and their F1 progeny (BALB/c × C57BL/6). Using multicolor flow cytometry, we show that S. ratti induces a distinct pattern of inhibitory checkpoint receptors by Foxp3⁺ Treg and Foxp3^- T cells. Intensity of expression was highest in C57BL/6 and lowest

SUBMITTER: Hartmann W 

PROVIDER: S-EPMC7810711 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature