Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [¹¹C]K-2, in healthy human subjects.

ABSTRACT: [¹¹C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients. This study aimed to estimate the radiation doses of [¹¹C]K-2 in various organs and calculate the effective dose after injection of [¹¹C]K-2 in healthy human subjects. Twelve healthy male subjects were registered and divided into two groups (370 or 555 MBq of [¹¹C]K-2), followed by 2 h whole-body scans. We estimated the radiation dose of each organ and then calculated the effective dose for each subject. The highest uptake of [¹¹C]K-2 was observed in

SUBMITTER: Hatano M 

PROVIDER: S-EPMC7810729 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature