Overexpression of β-Arrestins inhibits proliferation and motility in triple negative breast cancer cells.

ABSTRACT: β-Arrestins (βArrs) are intracellular signal regulating proteins. Their expression level varies in some cancers and they have a significant impact on cancer cell function. In general, the significance of βArrs in cancer research comes from studies examining GPCR signalling. Given the diversity of different GPCR signals in cancer cell regulation, contradictory results are inevitable regarding the role of βArrs. Our approach examines the direct influence of βArrs on cellular function and gene expression profiles by changing their expression levels in breast cancer cells, MDA-MB-231 and MDA-MB-468. Reducing expression of βArr1 or βArr2 tended to increase cell proliferation and invasion whereas increasing their expression levels inhibited them. The overexpression of βArrs caused cell cycle S-p

SUBMITTER: Bostanabad SY 

PROVIDER: S-EPMC7810837 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature