CX₃ CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer.

ABSTRACT: It has been reported that chemokine CX₃ CL1 can regulate various tumours by binding to its unique receptor CX₃ CR1. However, the effect of CX₃ CL1-CX₃ CR1 on the lung adenocarcinoma and lung squamous cell carcinoma is still unclear. Here, we showed that CX₃ CL1 can further invasion and migration of lung adenocarcinoma A549 and lung squamous cell carcinoma H520. In addition, Western blot and immunofluorescence test indicated CX₃ CL1 up-regulated the phosphorylation level of cortactin, which is a marker of cell pseudopodium. Meanwhile, the phosphorylation levels of c-Src and c-Abl, which are closely related to the regulation of cortactin phosphorylation, are elevated. Nevertheless, the src/abl inhibitor bosutinib and mutations

SUBMITTER: Fan M 

PROVIDER: S-EPMC7810942 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature