Direct analysis of surface chemicals using vibrating sharp-edge spray ionization mass spectrometry.

ABSTRACT:

Rationale

Direct analysis of chemicals on a surface using mass spectrometry (MS) is of great importance in forensics, food and drug safety, environmental monitoring, and defense. Solvent extraction-based surface analysis offers a convenient way of controlling the desorption conditions and applying internal standards. To date, it mainly relies on a separate electrospray process to nebulize and ionize the solvents. Here, we report a simple and stand-alone ionization system for the solvent extraction-based surface analysis without the need for high voltage, based on vibrating sharp-edge spray ionization (VSSI).

Methods

We modified the original VSSI device and developed a stand-alone, integrated surface sampling, and ionization system for MS analysis. By incorporating a micropip

SUBMITTER: Ranganathan N 

PROVIDER: S-EPMC7811172 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature