The influence of estrogen deficiency on the structural and mechanical properties of rat cortical bone.

ABSTRACT:

Background

Post-menopausal osteoporosis is a common health problem worldwide, most commonly caused by estrogen deficiency. Most of the information regarding the skeletal effects of this disease relates to trabecular bone, while cortical bone is less studied. The purpose of this study was to evaluate the influence of estrogen deficiency on the structure and mechanical properties of cortical bone.

Methods

Eight ovariectomized (OVH) and eight intact (control) Sprague Dawley rats were used.Structural features of femoral cortical bone were studied by light microscopy, scanning electron microscopy and synchrotron-based microcomputer-tomography and their mechanical properties determined by nano-indentation.

Results

Cortical bone of both study groups contains two distinct reg

SUBMITTER: Shipov A 

PROVIDER: S-EPMC7811283 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature