Comprehensive analysis of key lncRNAs in HCV-positive hepatocellular carcinoma.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Despite the therapeutic advances in HCC in the past few decades, the mortality rate of HCC is still high. Hepatitis C (HCV) infection is one of the major etiological risk factors of HCCs. However, the underlying mechanisms of HCV-induced hepatocarcinogenesis remain largely unclear.

Material and methods

Our study represented the comprehensive analysis of differentially expressed lncRNAs in HCV-positive HCC for the first time by analyzing the public dataset GSE17856. Co-expression network and gene ontology (GO) analysis revealed the functions of those differentially expressed lncRNAs.

Results

We identified 256 upregulated lncRNAs and 198 downregulated lncRNAs in HCV- positive HCC co

SUBMITTER: Liu J 

PROVIDER: S-EPMC7811325 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature