Identification and evaluation of novel vaccine candidates against Shigella flexneri through reverse vaccinology approach.

ABSTRACT: Shigellosis is a significant type of diarrhea that causes 160,000 deaths annually in a global scale. The mortality occurs mainly in children less than 5 years of age. No licensed vaccine is available, and conventional efforts for developing an effective and safe vaccine against shigellosis have not been succeeded yet. The reverse vaccinology is a novel promising method that screens genome or proteome of an organism for finding new vaccine candidates. In this study, through reverse vaccinology approach, new vaccine candidates against Shigella flexneri were identified and experimentally evaluated. Proteomes of S. flexneri were obtained from UniProt, and then outer membrane and extracellular proteins were predicted and selected for the evaluation of transmembrane domains, protein conservation

SUBMITTER: Hajialibeigi A 

PROVIDER: S-EPMC7811352 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature