Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation.

ABSTRACT: How does the brain internally represent a sequence of sensory information that jointly drives a decision-making behavior? Studies of perceptual decision-making have often assumed that sensory cortices provide noisy but otherwise veridical sensory inputs to downstream processes that accumulate and drive decisions. However, sensory processing in even the earliest sensory cortices can be systematically modified by various external and internal contexts. We recorded from neuronal populations across posterior cortex as mice performed a navigational decision-making task based on accumulating randomly timed pulses of visual evidence. Even in V1, only a small fraction of active neurons had sensory-like responses time-locked to each pulse. Here, we focus on how these 'cue-locked' neurons exhibited

SUBMITTER: Koay SA 

PROVIDER: S-EPMC7811404 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature