RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma.

ABSTRACT:

Background

The majority of lung cancers are adenocarcinomas, with the proportion being 40%. The patients are mostly diagnosed in the middle and late stages with metastasis and easy recurrence, which poses great challenge to the treatment and prognosis. Platinum-based chemotherapy is a primary treatment for adenocarcinoma, which frequently causes drug resistance. As a result, it is important to uncover the mechanisms of the chemoresponse of adenocarcinoma to platinum-based chemotherapy.

Methods

The genes from the dataset GSE7880 were gathered into gene modules with the assistance of weighted gene coexpression network analysis (WGCNA), the gene trait significance absolute value (|GS|), and gene module memberships (MM). The genes from hub gene modules were calculated with a pro

SUBMITTER: Wang N 

PROVIDER: S-EPMC7811416 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature