Identification and Validation of Autophagy-Related Genes in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Purpose

Autophagy plays essential roles in the development of COPD. We aim to identify and validate the potential autophagy-related genes of COPD through bioinformatics analysis and experiment validation.

Methods

The mRNA expression profile dataset GSE38974 was obtained from GEO database. The potential differentially expressed autophagy-related genes of COPD were screened by R software. Then, protein-protein interactions (PPI), correlation analysis, gene-ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were applied for the differentially expressed autophagy-related genes. Finally, RNA expression of top five differentially expressed autophagy-related genes was validated in blood samples from COPD patients and hea

SUBMITTER: Sun S 

PROVIDER: S-EPMC7811454 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature