Topological Data Analysis Approaches to Uncovering the Timing of Ring Structure Onset in Filamentous Networks.

ABSTRACT: In developmental biology as well as in other biological systems, emerging structure and organization can be captured using time-series data of protein locations. In analyzing this time-dependent data, it is a common challenge not only to determine whether topological features emerge, but also to identify the timing of their formation. For instance, in most cells, actin filaments interact with myosin motor proteins and organize into polymer networks and higher-order structures. Ring channels are examples of such structures that maintain constant diameters over time and play key roles in processes such as cell division, development, and wound healing. Given the limitations in studying interactions of actin with myosin in vivo, we generate time-series data of protein polymer interactions in c

SUBMITTER: Ciocanel MV 

PROVIDER: S-EPMC7811524 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature