IGF Bioregulation System in Benign and Malignant Thyroid Nodular Disease: A Systematic Review.

ABSTRACT:

Background/aim

The insulin-like growth factor bioregulation system is implicated in cancer biology. Herein, we aim to review the evidence on the expression of the insulin-like growth factor 1 and 2 (IGF1 and IGF2), their receptors (IGF-Rs) and IGF-binding proteins (IGFBPs) in thyroid tissue and their possible association with benign and malignant thyroid nodular diseases.

Materials and methods

We systematically reviewed Pubmed and Scopus databases up to May 2020. A total of 375 articles were retrieved and analyzed.

Results

Among 375 articles, 45 were included in this systematic review study. IGF1 was investigated in 31 studies, IGF2 in 1, IGF1 receptor in 15 and IGF-binding proteins in 13 articles. IGF1 expression in humans was dependent on the number and compound of

SUBMITTER: Karagiannis A 

PROVIDER: S-EPMC7811675 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature