Αlpha 5 subunit-containing GABA_A receptors in temporal lobe epilepsy with normal MRI.

ABSTRACT: GABA_A receptors containing the α5 subunit mediate tonic inhibition and are widely expressed in the limbic system. In animals, activation of α5-containing receptors impairs hippocampus-dependent memory. Temporal lobe epilepsy is associated with memory impairments related to neuron loss and other changes. The less selective PET ligand [¹¹C]flumazenil has revealed reductions in GABA_A receptors. The hypothesis that α5 subunit receptor alterations are present in temporal lobe epilepsy and could contribute to impaired memory is untested. We compared α5 subunit availability between individuals with temporal lobe epilepsy and normal structural MRI ('MRI-negative') and healthy controls, and interrogated the relationship between α5 subunit availability and episodic m

SUBMITTER: McGinnity CJ 

PROVIDER: S-EPMC7811756 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature