Astrocyte-Derived Lactate Modulates the Passive Coping Response to Behavioral Challenge in Male Mice.

ABSTRACT: Every organism inevitably experiences stress. In the face of acute, intense stress, for example, periods of passivity occur when an organism's actions fail to overcome the challenge. The occurrence of inactive behavior may indicate that struggling would most likely be fruitless. Repeated serious stress has been associated with mood disorders such as depression. The modulation of passive coping response patterns has been explored with a focus on the circuit level. However, the cellular and molecular mechanisms are largely uncharacterized. Here, we report that lactate is a key factor in the astrocytic modulation of the passive coping response to behavioral challenge in adult mice. We found increased extracellular lactate in the medial prefrontal cortex (mPFC) when mice experienced the forced

SUBMITTER: Yin YN 

PROVIDER: S-EPMC7811973 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature