An Innovative Prognostic Model Based on Four Genes in Asian Patient with Gastric Cancer.

ABSTRACT:

Purpose

Gastric cancer (GC) has substantial biological differences between Asian and non-Asian populations, which makes it difficult to have a unified predictive measure for all people. We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients.

Materials and methods

We investigated the differential gene expression between GC and normal tissues of GSE66229. Univariate, multivariate and Lasso Cox regression analyses were conducted to establish a four-gene-related prognostic model based on the risk score. The risk score was based on a linear combination of the expression levels of individual genes multiplied by their multivariate Cox regression coefficients. Validation of the prognostic model was conducted using The Cancer Genome Atlas

SUBMITTER: Chen J 

PROVIDER: S-EPMC7812008 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature