Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma Incorporating Hematological Biomarkers.

ABSTRACT:

Purpose

This study aimed to develop a nomogram for predicting pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC) by integrating hematological biomarkers and clinicopathological characteristics.

Materials and methods

Between 2003 and 2017, 306 ESCC patients who underwent neoadjuvant CRT followed by esophagectomy were analyzed. Besides clinicopathological factors, hematological parameters before, during, and after CRT were collected. Univariate and multivariate logistic regression analyses were performed to identify predictive factors for pCR. A nomogram model was built and internally validated.

Results

Absolute lymphocyte count (ALC), lymphocyte to monocyte ratio, albumin, hemoglobin,

SUBMITTER: Wu Y 

PROVIDER: S-EPMC7812014 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature