Association of Insulin, Metformin, and Statin with Mortality in Breast Cancer Patients.

ABSTRACT:

Purpose

This study investigated the association of insulin, metformin, and statin use with survival and whether the association was modified by the hormone receptor status of the tumor in patients with breast cancer.

Materials and methods

We studied 7,452 patients who had undergone surgery for breast cancer at Seoul National University Hospital from 2008 to 2015 using the nationwide claims database. Exposure was defined as a recorded prescription of each drug within 12 months before the diagnosis of breast cancer.

Results

Patients with prior insulin or statin use were more likely to be older than 50 years at diagnosis and had a higher comorbidity index than those without it (p < 0.01 for both). The hazard ratio (HR) for death with insulin use was 5.7 (p < 0.01), and t

SUBMITTER: Choi M 

PROVIDER: S-EPMC7812023 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature