Preparation and preliminary evaluation of hepatitis B core antigen virus like nanoparticles loaded with indocyanine green.

ABSTRACT:

Background

In recent years, nanotechnology has attracted a plethora of attention due of its ability to effectively diagnose and treat various tumors. Virus-like particles (VLPs) have good biocompatibility, are safe and non-toxic, and have an internal hollow space, and as such they are often used as nano drug carriers. In recent years, it has become one of the hot spots in the field of biopharmaceutical engineering.

Methods

In this study, the tumor-targeting peptide RGD (Arg-Gly-Asp) was genetically inserted into the major immunodominant region (MIR) of the hepatitis B virus core protein (HBc). A series of characterization, including stability and optical properties, were evaluated. A visual diagnosis and analysis of the efficacy against tumor cells were conducted at the cell

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7812214 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature