COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) patients with higher eosinophil counts are associated with increased clinical response to phosphodiesterase-4-inhibitors (PDE4i). However, the underlying inflammatory mechanisms associated with this increased response is not yet elucidated. This post hoc analysis focused on sputum gene expression in patients with chronic bronchitis who underwent 32-day treatment with two doses of the inhaled PDE4i CHF6001 (tanimilast) or placebo on top of triple therapy. Biological characterization and treatment effects were assessed between patients with different sputum eosinophil levels (eosinophil^high  ≥ 3%; eosinophil^low  < 3%) at baseline (primary samples) or at the end of the treatment of the placebo arm (validation samples). Forty-o

SUBMITTER: Singh D 

PROVIDER: S-EPMC7812250 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature