Tgfb3 and Mmp13 regulated the initiation of liver fibrosis progression as dynamic network biomarkers.

ABSTRACT: Liver fibrogenesis is a complex scar-forming process in the liver. We suggested that the liver first responded to chronic injuries with gradual changes, then reached the critical state and ultimately resulted in cirrhosis rapidly. This study aimed to identify the tipping point and key molecules driving liver fibrosis progression. Mice model of liver fibrosis was induced by thioacetamide (TAA), and liver tissues were collected at different time-points post-TAA administration. By dynamic network biomarker (DNB) analysis on the time series of liver transcriptomes, the week 9 post-TAA treatment (pathologically relevant to bridging fibrosis) was identified as the tipping point just before the significant fibrosis transition, with 153 DNB genes as key driving factors. The DNB genes were function

SUBMITTER: Guo J 

PROVIDER: S-EPMC7812286 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature