Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury

ABSTRACT: Abstract Cellular senescence is a widespread cellular programme that is characterized by permanent cell cycle arrest. Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thought to be a protective factor against cancer; however, it is now recognized that it has a dual effect on individuals. Co‐ordinated activation of cellular senescence provides advantages during embryogenesis, wound healing, tissue repair and inhibition of tumorigenesis. On the other hand, the aberrant generation and accumulation of abnormal senescent cells lead to the development of age‐related conditions and tissue deterioration. During acute kidney injury (AKI), the kidney faces multiple types of stressors and challenges, which can easily drive c

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7812305 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature