Longitudinal Associations Between Brain Volume and Knee Extension Peak Torque.

ABSTRACT:

Background

Muscle strength and brain volume decline with aging; changes in the brain manifested as change in volume may play a role in age-related strength loss, but this hypothesis has never been tested longitudinally. We examined longitudinal associations between brain volume changes and knee extension peak torque change in participants of the Baltimore Longitudinal Study of Aging.

Methods

Brain volumes and isokinetic concentric knee extension peak torque at 30 deg/s were measured in 678 participants (55.2% women; baseline age, 50.1-97.2 years; median follow-up time in those who visited two or more times (n = 375, 4.0 [interquartile range {IQR}, 2.3-5.0] years). Correlations between longitudinal changes in brain volumes and knee extension peak torque were examined using bi

SUBMITTER: Osawa Y 

PROVIDER: S-EPMC7812431 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature