Liver stiffness assessment as an alternative to hepatic venous pressure gradient for predicting rebleed after acute variceal bleed: A proof-of-concept study.

ABSTRACT:

Background and aim

Hepatic venous pressure gradient (HVPG), although an important determinant in predicting rebleeding after an episode of acute variceal bleed (AVB), is seldom utilized in clinical practice. We aimed to study the role of liver stiffness measurement (LSM) after variceal bleeding as a potential noninvasive predictor of rebleed.

Methods

This was a post hoc analysis of clinical trial of patients undergoing HVPG (postbleed HVPG) and LSM (postbleed LSM) assessment within 3-5 days of index AVB. HVPG response was assessed after 4 weeks of pharmacotherapy. Comparative assessment of long-term rebleeding rates stratified using postbleed LSM, postbleed HVPG, and HVPG response was performed. Decision curve analysis (DCA) was conducted to identify the most appropriate too

SUBMITTER: Agarwal S 

PROVIDER: S-EPMC7812463 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature