Association of Vitamin D Receptor Gene Polymorphisms with Metabolic Syndrome in Chinese Children.

ABSTRACT:

Purpose

To investigate the association between vitamin D receptor (VDR) gene polymorphisms and vitamin D deficiency, overweightness/obesity, and metabolic syndrome (MetS) in a cohort of Han children residing in Hangzhou, China.

Patients and methods

This study assessed 106 overweight/obese and 86 healthy (control) children. Five single-nucleotide polymorphisms (SNPs) in the VDR gene, namely, TaqI (rs731236 T > C), ApaI (rs7975232 C > A), BsmI (rs1544410 G > A), FokI (rs2228570 G >A), and Cdx2 (rs11568820 G > A), were genotyped by sequencing the total polymerase chain reaction products. The distributions of different genotypes and alleles were compared among different groups.

Results

The serum 25-hydroxyvitamin D (25(OH)D) concentration was significantly lower in overwe

SUBMITTER: Wang D 

PROVIDER: S-EPMC7812523 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature