Age of natural menopause onset in BRCA1/2 carriers - systematic review and meta-analysis.

ABSTRACT:

Introduction

Germinal pathogenic variants in BRCA1 and BRCA2 genes are associated with high risk of cancers, including breast, ovary, fallopian tubes and primary peritoneal. Non-oncological implications of germline pathogenic variants in BRCA1 and BRCA2 genes, complicating reproductive health are less described. The influence of BRCA1 and BRCA2 on age of natural menopause remains inconclusive and controversial.

Material and methods

PubMed database was searched for potentially relevant abstracts. Studies which were not case-control, cohort or cross-sectional studies were subsequently excluded. Reference lists from systematic reviews or meta-analyses, dealing with the topic of menopause and BRCA1 and BRCA2 germinal pathog

SUBMITTER: Kepczynski L 

PROVIDER: S-EPMC7812531 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature