Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group.
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ABSTRACT:
SUBMITTER: Bao Y
PROVIDER: S-EPMC7812609 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group.
Bao Yu Y Xu Qihao Q Wang Lin L Wei Yunfei Y Hu Baichun B Wang Jian J Liu Dan D Zhao Linxiang L Jing Yongkui Y
ACS medicinal chemistry letters 20210105 1
Psammaplin A (PsA) is a bromotyrosine disulfide dimer with histone deacetylase (HDAC) inhibition and acts through reduced monomer PsA-SH. We studied the connection of HDAC inhibition, cell growth inhibition, and apoptosis induction of PsA-SH by modifying the -SH group with deletion (<b>6a</b>) or replacement with hydroxamic acid (<b>10b</b>) or benzamide (<b>12g</b>). PsA-SH inhibits HDAC1/2/3 and <b>6a</b> loses the HDAC inhibition ability. <b>10b</b> inhibits HDAC1/2/3/6 while <b>12g</b> shows ...[more]
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