Aging and CMV discordance are associated with increased immune diversity between monozygotic twins.

ABSTRACT:

Background

Broadly, much of variance in immune system phenotype has been linked to the influence of non-heritable factors rather than genetics. In particular, two non-heritable factors: aging and human cytolomegavirus (CMV) infection, have been known to account for significant inter-individual immune variance. However, many specific relationships between them and immune composition remain unclear, especially between individuals over narrower age ranges. Further exploration of these relationships may be useful for informing personalized intervention development.

Results

To address this need, we evaluated 41 different cell type frequencies by mass cytometry and identified their relationships with aging and CMV seropositivity. Analyses were done using 60 healthy individuals, in

SUBMITTER: Yan Z 

PROVIDER: S-EPMC7812659 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature