Is gene expression among women with rheumatoid arthritis dysregulated during a postpartum flare?

ABSTRACT:

Background

To evaluate our hypotheses that, when rheumatoid arthritis (RA) flares postpartum, gene expression patterns are altered compared to (a) healthy women, (b) RA women whose disease activity is low or in remission postpartum, and (c) pre-pregnancy expression profiles.

Methods

Twelve women with RA and five healthy women were included in this pilot study. RA disease activity and postpartum flare were assessed using the Clinical Disease Activity Index (CDAI). Total RNA from frozen whole blood was used for RNA sequencing. Differential gene expression within the same women (within-group) over time, i.e., postpartum vs. third trimester (T3) or pre-pregnancy (T0), were examined, using a significance threshold of q < 0.05 and fold-change ≥ 2.

Results

Nine of the women

SUBMITTER: Wright M 

PROVIDER: S-EPMC7812735 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature