Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs.

ABSTRACT:

Background

The resistance against antimalarial drugs represents a global challenge in the fight and control of malaria. The Brazilian biodiversity can be an important tool for research and development of new medicinal products. In this context, toxinology is a multidisciplinary approach on the development of new drugs, including the isolation, purification, and evaluation of the pharmacological activities of natural toxins. The present study aimed to evaluate the cytotoxicity, as well as the antimalarial activity in silico and in vitro of four compounds isolated from Rhinella marina venom as potential oral drug prototypes.

Methods

Four compounds were challenged against 35 target proteins from P. falciparum and screened to evaluate their physicoche

SUBMITTER: Banfi FF 

PROVIDER: S-EPMC7812938 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature