Lack of survival advantage among re-resected elderly glioblastoma patients: a SEER-Medicare study.

ABSTRACT:

Background

The survival benefit of re-resection for glioblastoma (GBM) remains controversial, owing to the immortal time bias inadequately considered in many studies where re-resection was treated as a fixed, rather than a time-dependent factor. Using the Surveillance, Epidemiology, and End Results-Medicare (SEER-Medicare) database, we assessed treatment patterns for older adults and evaluated the association between re-resection and overall survival (OS), accounting for the timing of re-resection.

Methods

This retrospective cohort study included elderly patients (age ≥66) in the SEER-Medicare linked database diagnosed with GBM between 2006 and 2015 who underwent initial resection. Time-dependent Cox regression was used to assess the association between re-resection and OS,

SUBMITTER: Goldman DA 

PROVIDER: S-EPMC7813163 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature