Preoperative and early postoperative seizures in patients with glioblastoma-two sides of the same coin?

ABSTRACT:

Background

Symptomatic epilepsy is a common symptom of glioblastoma, which may occur in different stages of disease. There are discrepant reports on association between early seizures and glioblastoma survival, even less is known about the background of these seizures. We aimed at analyzing the risk factors and clinical impact of perioperative seizures in glioblastoma.

Methods

All consecutive cases with de-novo glioblastoma treated at our institution between 01/2006 and 12/2018 were eligible for this study. Perioperative seizures were stratified into seizures at onset (SAO) and early postoperative seizures (EPS, ≤21days after surgery). Associations between patients characteristics and overall survival (OS) with SAO and EPS were addressed.

Results

In the final cohort (

SUBMITTER: Ahmadipour Y 

PROVIDER: S-EPMC7813191 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature