Mortality and Obesity Among U.S. Older Adults: The Role of Polygenic Risk.

ABSTRACT:

Objectives

To examine the relationship between obesity and mortality as a function of polygenic risk for obesity among older U.S. adults.

Method

Using data from the 1994-2014 Health and Retirement Study in conjunction with genome-wide data, we evaluated the risk of mortality as a function of obesity classification, an individual's polygenic risk score (PGS) for obesity, and their interaction, stratified by sex. We conducted our analyses using cox proportional hazard models.

Results

Among those with an average PGS for obesity (8,143 [68.8%]), obese I (hazard ratio [HR] = 0.79, p = .336) adults show no difference in their risk for mortality and obese II/III (HR = 3.17, p = .000) adults present higher risk of mortality relative to non-obese adults. The interaction of obe

SUBMITTER: Vinneau JM 

PROVIDER: S-EPMC7813195 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature