Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation.

ABSTRACT: The integration of multiple signalling pathways that co-ordinate T cell metabolism and transcriptional reprogramming is required to drive T cell differentiation and proliferation. One key T cell signalling module is mediated by extracellular signal-regulated kinases (ERKs) which are activated in response to antigen receptor engagement. The activity of ERKs is often used to report antigen receptor occupancy but the full details of how ERKs control T cell activation is not understood. Accordingly, we have used mass spectrometry to explore how ERK signalling pathways control antigen receptor driven proteome restructuring in CD8+ T cells to gain insights about the biological processes controlled by ERKs in primary lymphocytes. Quantitative analysis of >8000 proteins identified 900 ERK regulate

SUBMITTER: Damasio MP 

PROVIDER: S-EPMC7813476 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature