Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.

ABSTRACT: Astrocytes tile the central nervous system and are widely implicated in brain diseases, but the molecular mechanisms by which astrocytes contribute to brain disorders remain incompletely explored. By performing astrocyte gene expression analyses following 14 experimental perturbations of relevance to the striatum, we discovered that striatal astrocytes mount context-specific molecular responses at the level of genes, pathways, and upstream regulators. Through data mining, we also identified astrocyte pathways in Huntington's disease (HD) that were reciprocally altered with respect to the activation of striatal astrocyte G protein-coupled receptor (GPCR) signaling. Furthermore, selective striatal astrocyte stimulation of the G_i-GPCR pathway in vivo corrected several HD-associated

SUBMITTER: Yu X 

PROVIDER: S-EPMC7813554 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature